The Proline 12 Alanine Substitution in the PPARγ2 Gene is Associated With Increased Extent of Coronary Artery Disease in Men

Abstract

Objective: To determine whether there is an independent association between the Pro12Ala polymorphism in the peroxisome proliferator-activated-receptor γ2 (PPARγ2)-gene and the extent of coronary artery disease in men.

Research Design and Methods: We determined the Pro12Ala polymorphism in the PPARγ2 gene in 240 male patients undergoing elective coronary angiograpy, and quantitated the degree of CAD by evaluating the extent-score which better correlates with known risk factors than other measures of CAD.

Results: The presence of the 12Ala allele was significantly associated with higher CAD extent (r=0.27, p<0.01). CAD extent was also correlated with the extent of insulin resistance (HOMA, r=0.22, p<0.01), and age (r=0.16, p<0.05). Multivariate analysis revealed an independent association between the 12Ala allele PPARγ2 with extent-score (β=0.32, p<0.01).

Conclusions: The 12Ala allele in PPARγ2 correlates with a significantly increased CAD extent in men, which suggest that lower activity of the transcription factor PPARγ2 is associated with more severe CAD.

Key words

coronary artery disease - cardiovascular incidences - coronary syndrome - receptors - signal transduction

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1 Both authors contributed equally

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